SAFETY CONSIDERATIONS WITH BLOOD FLOW RESTRICTED RESISTANCE TRAINING

Authors

  • Alan Kacin University of Ljubljana Faculty of Health Sciences
  • Benjamin Rosenblatt English Institute of Sport Bisham Abbey National Sports Centre
  • Tina Grapar Žargi University of Ljubljana Faculty of Health Sciences
  • Anita Biswas English Institute of Sport Bisham Abbey National Sports Centre

Abstract

 

Blood flow restricted resistance (BFRR) training with pneumatic tourniquet has been suggested as an alternative for conventional weight training due to the proven benefits for muscle strength and hypertrophy using relatively low resistance, hence reducing the mechanical stress across a joint. As such, it has become an important part of rehabilitation programs used in either injured or operated athletes. Despite a general consensus on effectiveness of BFRR training for muscle conditioning, there are several uncertainties regarding the interplay of various extrinsic and intrinsic factors on its safety and efficiency, which are being reviewed from a clinical perspective. Among extrinsic factors tourniquet cuff pressure, size and shape have been identified as key for safety and efficiency. Among intrinsic factors, limb anthropometrics, patient history and presence of cardiac, vascular, metabolic or peripheral neurologic conditions have been recognized as most important. Though there are a few potential safety concerns connected to BFRR training, the following have been identified as the most probable and health-hazardous: (a) mechanical injury to the skin, muscle, and peripheral nerves, (b) venous thrombosis due to vascular damage and disturbed hemodynamics and (c) augmented arterial blood pressure responses due to combined high body exertion and increased peripheral vascular resistance. Based on reviewed literature and authors’ personal experience with the use of BFRR training in injured athletes, some guidelines for its safe application are outlined. Also, a comprehensive risk assessment tool for screening of subjects prior to their inclusion in a BFRR training program is being introduced.

 

Author Biographies

Alan Kacin, University of Ljubljana Faculty of Health Sciences

Department of Physiotherapy

Tina Grapar Žargi, University of Ljubljana Faculty of Health Sciences

Department of  Physiotherapy

References

Abe, T., Fujita, S., Nakajima, T., et al. (2010). Effects of low-intensity cycle training with restricted leg blood flow on thigh muscle volume and VO2max in young men. Journal of Sports Science and Medicine, 9(3), 452-458.

Allison, R. C., Bedsole, D. L. (2003). The other medical causes of rhabdomyolysis. American Journal of the Medical Sciences, 326(2), 79-88.

Ames, A., Nesbett, F. B. (1983). Patho-physiology of ischemic cell-death. Time of onset of irreversible damage - importance of the different components of the ischemic insult. Stroke, 14(2), 219-26.

Blaisdell, F. W. (2002). The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Vascular, 10(6), 620-630.

Bolton, C. F., McFarlane, R. M. (1978). Human pneumatic tourniquet paralysis. Neurology, 28(8), 787-93.

Brown, D. D., Brenner, C. (1944). Paralysis of nerve induced by direct pressure and by tourniquet. Archives of Neurology and Psychiatry, 51(1), 1-26.

Carden, D. L., Granger, D. N. (2000). Pathophysiology of ischaemia-reperfusion injury. Journal of Pathology, 190(3), 255-266.

Clark, B. C., Manini, T. M., Hoffman, R. L., et al. (2011). Relative safety of 4 weeks of blood flow-restricted resistance exercise in young, healthy adults. Scandinavian Journal of Medicine & Science in Sports, 21(5), 653-662.

Cook, S. B., Murphy, B. G., Labarbera, K. E. (2013). Neuromuscular Function after a Bout of Low-Load Blood Flow-Restricted Exercise. Medicine & Science in Sports & Exercise, 45(1), 67-74.

Crenshaw, A. G., Hargens, A. R., Gershuni, D. H., Rydevik, B. (1988). Wide tourniquet cuffs more effective at lower inflation pressures. Acta orthopaedica Scandinavica, 59(4), 447-451.

de Groot, P. C. E., Thijssen, D. H. J., Sanchez, M., Ellenkamp, R., Hopman, M. T. E. (2010). Ischemic preconditioning improves maximal performance in humans. European journal of applied physiology, 108(1), 141-146.

Downs, M. E., Hackney, K. J., Martin, D., et al. (2014). Acute Vascular and Cardiovascular Responses to Blood Flow-Restricted Exercise. Medicine & Science in Sports & Exercise, 46(8), 1489-1497.

Estebe, J. P., Davie,s J. M., Richebe, P. (2011). The pneumatic tourniquet: mechanical, ischaemia-reperfusion and systemic effects. European Journal of Anaesthesiology, 28(6), 404-411.

Estebe, J. P., Le Naoures, A., Chemaly, L., Ecoffey, C. (2000). Tourniquet pain in a volunteer study: effect of changes in cuff width and pressure. Anaesthesia, 55(1), 21-26.

Evans, C., Vance, S., Brown, M. (2010). Short-term resistance training with blood flow restriction enhances microvascular filtration capacity of human calf muscles. Journal of Sports Sciences, 28(9), 999-1007.

Fitzgibbons, P. G., DiGiovanni, C., Hares, S., Akelman, E. (2012). Safe Tourniquet Use: A Review of the Evidence. Journal of the American Academy of Orthopaedic Surgeons, 20(5), 310-319.

Fry, C. S., Glynn, E. L., Drummond, M. J., et al. (2010). Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. Journal of applied physiology. 108(5), 1199-1209.

Graham, B., Breault, M. J., McEwen, J. A., McGraw, R. W. (1993). Occlusion of arterial flow in the extremities at subsystolic pressures through the use of wide tourniquet cuffs. Clinical Orthopaedics & Related Research, 286, 257-261.

Gregersen, G., Servo, C., Borsting, H., Theil, P. (1978). Myoinositol and function of peripheral-nerves in human diabetics - controlled clinical-trial. Acta Neurologica Scandinavica, 58(4), 241-248.

Gregory, C. M., Vandenborne, K., Dudle, G. A. (2001). Metabolic enzymes and phenotypic expression among human locomotor muscles. Muscle and Nerve, 24(3), 387-393.

Gualano, B., Neves, M., Jr., Lima, F. R., et al. (2010). Resistance Training with Vascular Occlusion in Inclusion Body Myositis: A Case Study. Medicine & Science in Sports & Exercise, 42(2), 250-254.

Heitkamp, H. C. (2015). Training with blood flow restriction - mechanisms, gain in strength and safety. The Journal of Sports Medicine and Physical Fitness, 55(5), 9-15.

Hughes, S. F., Hendricks, B. D., Edwards, D. R, Bastawrous, S. S., Roberts, G. E., Middleton, JF. (2007). Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. Journal of Inflammation (Lond), 4, 12.

Hughes, S. F., Hendricks, B. D., Edwards, D. R., Middleton, J. F. (2010). Tourniquet-applied upper limb orthopaedic surgery results in increased inflammation and changes to leukocyte, coagulation and endothelial markers. PLoS One, 5, e11846.

Hunt, J., Galea, D., Tufft, G., Bunce, D., Ferguson, R. (2013). Time course of regional vascular adaptations to low load resistance training with blood flow restriction. Journal of applied physiology, 115(3), 403-411.

Hunt, J., Walton, L., Ferguson, R. (2012). Brachial artery modifications to blood flow-restricted handgrip training and detraining. Journal of applied physiology, 112(6), 956-961.

Iida, H., Kurano, M., Takano, H., et al. (2007). Hemodynamic and neurohumoral responses to the restriction of femoral blood flow by KAATSU in healthy subjects. European journal of applied physiology, 100(3), 275-285.

Iversen, E., Rostad, V. (2010). Low-Load Ischemic Exercise-Induced Rhabdomyolysis. Clinical Journal of Sport Medicine, 20(3), 218-219.

Kacin, A., Strazar, K., Palma, P., Podobnik, G. (2011). Effectiveness of low-load ischemic resistance exercise in treating chronic disuse atrophy of knee extensor muscles: a case report. In 16th International WCPT Congress (p. eS575). Amsterdam: Elsevier, Physiotherapy, 97(S1).

Kacin, A., Strazar, K. (2011). Frequent low-load ischemic resistance exercise to failure enhances muscle oxygen delivery and endurance capacity. Scandinavian Journal of Medicine & Science in Sports, 21(6), e231-241.

Karabulut, M., Bemben, D. A., Sherk, V. D., Anderson, M. A., Abe, T., Bemben, M. G. (2011). Effects of high-intensity resistance training and low-intensity resistance training with vascular restriction on bone markers in older men. European journal of applied physiology, 111(8), 1659-1667.

Karabulut, M., McCarron, J., Abe, T., Sato, Y., Bemben, M. (2011). The effects of different initial restrictive pressures used to reduce blood flow and thigh composition on tissue oxygenation of the quadriceps. Journal of Sports Sciences, 29(9), 951-958.

Lang, F., Ritter, M., Gamper, N., et al. (2000). Cell volume in the regulation of cell proliferation and apoptotic cell death. Cellular Physiology and Biochemistry, 10(5-6), 417-428.

Larsen, U. T., Hommelgaard, P. (1987). Pneumatic tourniquet paralysis following intravenous regional analgesia. Anaesthesia, 42(5), 526-528.

Levick, J., Michel, C. (2010). Microvascular fluid exchange and the revised Starling principle. Cardiovascular Research, 87(2), 198-210.

Loenneke, J., Fahs, C., Rossow, L., Abe, T., Bemben, M. (2012). The anabolic benefits of venous blood flow restriction training may be induced by muscle cell swelling. Medical Hypotheses, 78(1), 151-154.

Loenneke, J., Wilson, J., Balapur, A., Thrower, A., Barnes, J., Pujol, T. (2012). Time under tension decreased with blood flow-restricted exercise. Clinical Physiology and Functional Imaging, 32(4), 268-273.

Loenneke, J., Wilson, J., Marin, P., Zourdos, M., Bemben, M. (2012). Low intensity blood flow restriction training: a meta-analysis. European journal of applied physiology, 112(5), 1849-1859.

Loenneke, J. P., Fahs, C. A., Rossow, L. M., et al. (2012). Effects of cuff width on arterial occlusion: implications for blood flow restricted exercise. European journal of applied physiology, 112(8), 2903-2912.

Loenneke, J. P., Thiebaud, R. S., Abe, T., Manfro, I. G., Marin, P. J. (2013). Acute blood flow restricted exercise to treat Duchenne muscular dystrophy: would it be efficacious? Frontiers in physiology, 4, 114-114.

Loenneke, J. P., Wilson, J. M., Wilson, G. J., Pujol, T. J., Bemben, M. G. (2011). Potential safety issues with blood flow restriction training. Scandinavian Journal of Medicine & Science in Sports, 21(4), 510-518.

Loenneke, J. P., Young, K. C., Wilson, J. M., Andersen, J. C. (2013). Rehabilitation of an osteochondral fracture using blood flow restricted exercise: a case review. Journal of Bodywork and Movement Therapies, 17(1), 42-45.

Lundborg, G., Gelberman, R. H., Minteer-Convery, M., Lee Y. F., Hargens, A. R. (1982). Median nerve compression in the carpal tunnel--functional response to experimentally induced controlled pressure. The Journal of Hand Surgery, 7(3), 252-259.

Madarame, H., Kurano, M., Fukumura, K., Fukuda, T., Nakajima, T. (2013). Haemostatic and inflammatory responses to blood flow-restricted exercise in patients with ischaemic heart disease: a pilot study. Clinical Physiology and Functional Imaging, 33(1), 11-17.

Madarame, H., Kurano, M., Takano, H., et al. (2010). Effects of low-intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects. Clinical Physiology and Functional Imaging, 30(3), 210-213.

Manini, T. M., Clark, BC. (2009). Blood flow restricted exercise and skeletal muscle health. Exercise & Sport Sciences Reviews, 37(2), 78-85.

Markert, C. D., Ambrosio, F., Call, J. A., Grange, R. W. (2011). Exercise and duchenne muscular dystrophy: toward evidence-based exercise prescription. Muscle and Nerve, 43(4), 464-478.

Moore, M. R., Garfin, S. R., Hargens, A. R. (1987). Wide tourniquets eliminate blood-flow at low inflation pressures. The Journal of Hand Surgery, 12(6), 1006-1011.

Nakajima, T., Iida, H., Kurano, M., et al. (2006). Use and safety of KAATSU training: results of national survey. International Journal of KAATSU Training Research, 2(1), 5-13.

Newman, R. J., Muirhead, A. (1986). A safe and effective low pressure tourniquet. A prospective evaluation. The journal of bone and joint surgery Br, 68(4), 625-628.

Nielsen, J., Aagaard, P., Bech, R., et al. (2012). Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction. The Journal of Physiology (London), 590(17), 4351-4361.

Ochoa, J., Fowler, T. J., Gilliatt, R. W. (1972). Anatomical changes in peripheral-nerves compressed by a pneumatic tourniquet. Journal of Anatomy, 113(3), 433-455.

Ohta, H., Kurosawa, H., Ikeda, H., Iwase, Y., Satou, N., Nakamura, S. (2003). Low-load resistance muscular training with moderate restriction of blood flow after anterior cruciate ligament reconstruction. Acta orthopaedica Scandinavica, 74(1), 62-68.

Olivecrona C., Tidermark, J., Hamberg, P., Ponzer, S., Cederfjäll, C. (2006). Skin protection underneath the pneumatic tourniquet during total knee arthroplasty: a randomized controlled trial of 92 patients. Acta Orthopaedica, 77(3), 519-523.

Park, S., Kim, J. K., Choi, H. M., Kim, H. G., Beekley, M. D., Nho, H. (2010). Increase in maximal oxygen uptake following 2-week walk training with blood flow occlusion in athletes. European journal of applied physiology, 109(4), 591-600.

Patterson, S., Ferguson, R. (2010). Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women. European journal of applied physiology, 108(5), 1025-1033.

Pedowitz, R. A., Gershuni, D. H., Botte, M. J., Kuiper, S., Rydevik, B. L, Hargens, A. R. (1993). The use of lower tourniquet inflation pressures in extremity surgery facilitated by curved and wide tourniquets and an integrated cuff inflation system. Clinical Orthopaedics & Related Research, 287, 237-244.

Pedowitz, R. A., Gershuni, D. H., Schmidt, A. H., Fridén, J., Rydevik, B. L., Hargens, A. R. (1991). Muscle injury induced beneath and distal to a pneumatic tourniquet: A quantitative animal study of effects of tourniquet pressure and duration. The Journal of Hand Surgery, 16(4), 610-621.

Pope, Z., Willardson, J., Schoenfeld, B. (2013). Exercise and blood flow restriction. Journal of Strength & Conditioning Research, 27(10), 2914-2926.

Poton, R., Doederlein Polito M. (2014). Hemodynamics responses during lower-limb resistance exercise with blood flow restriction in healthy subjects. The Journal of Sports Medicine and Physical Fitness. Ahead of print.

Renzi, C. P., Tanaka, H., Sugawara, J. (2010). Effects of Leg Blood Flow Restriction during Walking on Cardiovascular Function. Medicine & Science in Sports & Exercise, 42(2), 726-732.

Rossow, L., Fahs, C., Loenneke, J., et al. (2012). Cardiovascular and perceptual responses to blood-flow-restricted resistance exercise with differing restrictive cuffs. Clinical Physiology and Functional Imaging, 32(5), 331-337.

Rossow, L. M., Fahs, C. A., Sherk, V. D., Seo D-i, Bemben, D. A., Bemben, M. G. (2011). The effect of acute blood-flow-restricted resistance exercise on postexercise blood pressure. Clinical Physiology and Functional Imaging, 31(6), 429-434.

Satoh, I. (2011). Kaatsu Training: Application to Metabolic Syndrome. International Journal of KAATSU Training Research, 7(1), 7-12.

Sima, A. A. F., Thomas, P. K., Ishii, D., Vinik, A. (1997). Diabetic neuropathies. Diabetologia, 40(3), B74-B77.

Sugaya, M., Yasuda, T., Suga, T., Okita, K., Abe, T. (2011). Change in intramuscular inorganic phosphate during multiple sets of blood flow-restricted low-intensity exercise. Clinical Physiology and Functional Imaging, 31(5), 411-413.

Takada, S., Okita, K., Suga, T., et al. (2012). Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions. Journal of applied physiology, 113(2), 199-205.

Takano, H., Morita, T., Iida, H., et al. (2005). Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. European journal of applied physiology, 95(1), 65-73.

Takarada, Y., Sato, Y., Ishii, N. (2002). Effects of resistance exercise combined with vascular occlusion on muscle function in athletes. European journal of applied physiology, 86(4), 308-314.

Takarada, Y., Takazawa, H., Sato, Y., Takebayashi, S., Tanaka, Y., Ishii, N. (2000). Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. Journal of applied physiology, 88(6), 2097-2106.

Tuncali, B., Karci, A., Tuncali, B. E., et al. (2006). A New Method for Estimating Arterial Occlusion Pressure in Optimizing Pneumatic Tourniquet Inflation Pressure. Anesthesia & Analgesia, 102(6), 1752-1757.

Umbel, J. D., Hoffman, R. L., Dearth, D. J., Chleboun, G. S., Manini, T. M., Clark, B. C. (2009). Delayed-onset muscle soreness induced by low-load blood flow-restricted exercise. European journal of applied physiology, 107(6), 687-695.

Van der Spuy, L.-A. (2012). Complications of the arterial tourniquet. Southern African journal of anaesthesia and analgesia, 18(1), 14-18.

Vieira, P. J. C., Chiappa, G. R., Umpierre, D., Stein, R., Ribeiro, J. P. (2013). Hemodynamic Responses to Resistance Exercise With Restricted Blood Flow in Young and Older Men. Journal of Strength & Conditioning Research, 27(8), 2288-2294.

Wakai A., Wang, J. H., Winter, D. C., Street, J. T., O'Sullivan, R. G., Redmond, H. P. (2001). Tourniquet-induced systemic inflammatory response in extremity surgery. Journal of Trauma-Injury Infection & Critical Care, 51(5), 922-926.

Wernbom, M., Augustsson, J., Raastad, T. (2008). Ischemic strength training: a low-load alternative to heavy resistance exercise? Scandinavian Journal of Medicine & Science in Sports, 18(4), 401-416.

Wernbom, M., Paulsen, G., Nilsen, T. S., Hisdal, J., Raastad, T. (2012). Contractile function and sarcolemmal permeability after acute low-load resistance exercise with blood flow restriction. European journal of applied physiology, 112(6), 2051-2063.

Yasuda, T., Brechue, W. F., Fujita, T., Shirakawa, J., Sato, Y., Abe, T. (2009). Muscle activation during low-intensity muscle contractions with restricted blood flow. Journal of Sports Sciences, 27(5), 479-489.

Yasuda, T., Fukumura, K., Fukuda, T., et al. (2014). Effects of low-intensity, elastic band resistance exercise combined with blood flow restriction on muscle activation. Scandinavian Journal of Medicine & Science in Sports, 24(1), 55-61.

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27-11-2015

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Kacin, A., Rosenblatt, B., Grapar Žargi, T., & Biswas, A. (2015). SAFETY CONSIDERATIONS WITH BLOOD FLOW RESTRICTED RESISTANCE TRAINING. Annales Kinesiologiae, 6(1), pp. 3–26. Retrieved from http://194.249.2.56/index.php/AK/article/view/96

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